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The medicaments are prepared most often from a combination of two or more plant products, which many a time many contain active constituents with multiple physiological activities and could be used in treating various disease conditions [ 7].
Interestingly, the C. elegans genome encodes a massively expanded NHR family; we speculate that some of the multiple physiological activities governed by individual mammalian NHRs may be distributed among multiple members of the C. elegans family, potentially focusing and simplifying functional analyses.
Retinoids (vitamin A and its metabolites) regulate multiple physiological activities, such as vision, morphogenesis, cell proliferation, and differentiation (Sporn et al, 1994).
Thyroid hormones (THs), particularly triiodothyronine (T3), are potent regulators of multiple physiological activities, including cellular metabolic rate, heart and digestive functions, muscle function, brain development, and bone maintenance [ 1, 2].
Matrix metalloproteinases (MMPs), zinc-dependent endopeptidases, are responsible for the degradation of various components of the extracellular matrix (ECM), involved in multiple physiological activities including the regulation of cell cycle, apoptosis, and angiogenesis [44].
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These results indicate that the bacterial flagellin influences expression of genes involved in multiple physiological and biochemical activities in rice.
NO is thus a vasodilator that mediates multiple physiological and pathophysiological activities in the cardiovascular system and protects against the development of atherosclerosis [ 13].
PGC-1α [ 19, 20], a co-activator that coordinates multiple physiological cues for mitochondrial biogenesis and activity, is highly expressed in BAT but only expressed at low levels in WAT [ 21].
Spontaneous activity of neurons was the earliest electrical activity and had multiple physiological functions in the early development.
Furthermore, PGC-1α has been shown to coordinate multiple physiological cues for mitochondrial biogenesis and activity [13].
In conclusion, P38MAPK signaling pathway regulated various physiological activities of LR through multiple signaling pathways.
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