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Multiple oral dosing of MK-8931 lowered Aβ levels in the CSF by over 90%.
5-FU pharmacokinetics during multiple oral dosing of eniluracil and 5-FU have been reported by Baker et al (2000).
The initial elimination half-life in normal dogs has been reported to range from 37−73h after multiple oral dosing [ 96].
To characterize the plasma concentration vs. time profile following administration of LY2878735 after single or multiple oral dosing, a variety of compartmental models were evaluated.
The objectives of this first-in-human study were to assess the safety and tolerability of KAE609 in healthy adult volunteers after single and multiple oral dosing and to assess the pharmacokinetics after single (including food effect) and multiple dosing.
The objectives of this first-in-human study were to assess the safety and tolerability of KAF156 in healthy adult volunteers after single and multiple oral dosing and to assess the pharmacokinetics after single dosing (including food effect) and multiple dosing.
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Hayes KC, Potter PJ, Hsieh JT, Katz MA, Blight AR, Cohen R. Pharmacokinetics and safety of multiple oral doses of sustained-release 4-aminopyridine (Fampridine-SR) in subjects with chronic, incomplete spinal cord injury.
Significant tivantinib accumulation in plasma was observed after multiple oral doses.
Multiple oral doses of genistein significantly protected mice against γ-irradiation [ 31, 32].
The multiple oral doses of larazotide acetate used in this study were well tolerated.
(Table 3) On DL 1, pre-treatment with multiple oral doses of 200 mg b.i.d.
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