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Overall, mean PK parameters of apatinib after single and multiple oral dose administration are summarized in Table 2.
CF101, in single and multiple oral dose studies, was found to be safe and well tolerated, and the pharmacokinetics were linearly proportional to dose [ 14].
56, 77 A pharmacodynamic investigation was performed in a randomized, placebo controlled, and multiple oral dose study in 64 fasted, female volunteers.
In 1997, we summarised the results of surveillance studies of over 2 million infants in four different countries using different multiple oral dose schedules and parenteral administration of vitamin K.
Following a multiple oral dose, a tendency for initial reduction and subsequent increase of mean blood flow values in the iris was observed for carvedilol, and no effect on blood flow was observed for nebivolol.
The secondary objectives were to determine the single and multiple oral dose PK of SMT19969, to assess the effect of food on the systemic exposure of SMT19969, to assess the effect of multiple oral doses of SMT19969 on gut microbiota (via assessment of faecal samples) and to determine concentrations of SMT19969 in faecal samples.
Similar(54)
Hayes KC, Potter PJ, Hsieh JT, Katz MA, Blight AR, Cohen R. Pharmacokinetics and safety of multiple oral doses of sustained-release 4-aminopyridine (Fampridine-SR) in subjects with chronic, incomplete spinal cord injury.
Significant tivantinib accumulation in plasma was observed after multiple oral doses.
Multiple oral dosing of MK-8931 lowered Aβ levels in the CSF by over 90%.
Multiple oral doses of genistein significantly protected mice against γ-irradiation [ 31, 32].
The multiple oral doses of larazotide acetate used in this study were well tolerated.
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