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In all cases, in different numbers, bizarre giant cells with large, lobulated, or multiple nuclei were also admixed, some of them morphologically imitating Reed-Sternberg cells, lipoblasts, or ganglion cells; they showed distinct nucleoli or intranuclear inclusions.

Fractions of MCF-7 cells containing the multiple nuclei were increased after doxorubicin treatment (inserted table in Figure 3).

During the generation of doxorubicin resistant MCF-7 clones, multiple nuclei were detected in MCF-7 cells.

Mid-coronal fragments of medial tibial plateaux were divided into three equal parts (external, central and internal) and TRAP positive cells with multiple nuclei were counted in each part as positive MGCs under light Axioskop-50 microscope (Carl Zeiss Ltd., Welwyn Garden City, UK), using a 40× objective lens.

By using the definition of PGCCs set by Zhang et al. that characterized a PGCC as a cancer cell with a nucleus of at least three times larger than that of a diploid cancer cell [ 10], it was observed that PGCCs with giant or multiple nuclei were present in both low-grade and high-grade human OSCs.

Similar(55)

Following 48 h of incubation, a complete layer of syncytium, positive for β-hCG and with multiple nuclei, was observed overlaying β-hCG-negative mononucleated CTBs.

The ratio of MCF-7 cells with the multiple nuclei is significantly increased, before doxorubicin-resistant MCF-7 clones emerged, compared to the drug sensitive control MCF-7 cells.

The Metacoronympha-morph was larger, and the distinctive multiple spirals of nuclei were clearly observed and contrasted with the single ring of karyomastigonts in the Coronympha-morph (Figure 1I & K).

In addition, multiple dark nuclei are observed in the liquid-like particles prior to carbonization.

Muscle sarcoplasms are also unique in that they are shared between multiple nuclei and are much larger in volume compared to many other cell types.

This geometrical model is often confounded as multiple nuclei can be so close as to appear like one large, arbitrary-shaped nucleus.

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