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In particular, we show that these rat iPS cells can efficiently differentiate to multiple neuronal lineages including midbrain-like dopaminergic neurons which will serve as invaluable platform for bioassay and cell transplantation studies of PD.
4) In the present assay, authors used TH as a readout marker to address neuronal subtype (dopaminergic neuron -directed differeneuron -directedeir hit compoundifferentiatione differentiation of multiple neuronal lineages without selectivity for specific neuronal subuttheir
At present, it is not clear at which stage of differentiation ESCs become competent to produce multiple neuronal lineages in response to the niche of the embryonic brain.
Selamectin increases the differentiation of multiple neuronal lineages from human pluripotent stem cells.
We speculated that exposure to VPA from gastrulation could affect common steps in the differentiation of multiple neuronal lineages.
Transcription factors of the bHLH family direct the proliferation, specification and maturation of multiple neuronal lineages (Atchley and Fitch, 1997; Guillemot, 1999; Ross et al., 2003).
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This screening platform has enabled us to identify selamectin and show that it increases the production of multiple neuronal lineage types including DA, 5-HT, GABA, and Islet+ neurons as well as olig2+ oligodendrocytes.
ASThiPS cells show a pluripotent gene expression signature, display an ES-like cell cycle profile, differentiate into the three germ layers in vitro and in vivo, and generate multiple neuronal cell lineages following directed differentiation.
Neural stem cells (NSCs) are capable of self-renewal and generate multiple neuronal and glial lineages, which exist in both the fetal and adult nervous system in mammals.
Additionally, through RNAi screening of these genes, mex3-1 was identified as essential for differentiation into multiple planarian cell lineages (eye, neuronal lineages, and epithelium).
This paradigm of stem cell plasticity in the CNS was, however, challenged by controversial studies using BM chimeric mice reporting that stem cell populations from distinct lineages, which typically reside in the BM, could form multiple neuronal cell types in the brain [ 6, 27].
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various neuronal lineages
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multiple neuronal networks
multiple neuronal receptors
multiple neuronal connections
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multiple barcode lineages
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multiple eukaryotic lineages
multiple neuronal inclusions
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multiple neuronal biomarkers
multiple clonal lineages
multiple neuronal assemblies
multiple neural lineages
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