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ALS is a disorder with heterogeneous onset, which then leads to common final pathways involving multiple neuronal compartments that span both the central and peripheral nervous system.
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Databases on the properties of neurons, CellPropDB, and neuronal compartments, NeuronDB, store information on the neuronal and compartment distribution of membrane proteins ion channels and receptors and neurotransmitters which are known to be present (or known to be absent) from a particular neuron or neuronal compartment.
Thus, SytGFP represents a valuable marker to separate synapses from other neuronal compartments in aminergic neurons.
The transcription factor Elk-1 resides within multiple brain areas both in nuclear and extranuclear neuronal compartments.
Peyron, C. et al. Neurons containing hypocretin (orexin) project to multiple neuronal systems.
Thus, the Hox code for both musculoskeletal and neuronal compartments is conserved for the pectoral motor system, despite anatomical differences in location along the anterior posterior axis.
The derived neuronal cells express MAP2, Tau, glutamate, GABA and Islet-1, indicating the existence of multiple neuronal subtypes.
We then introduce our modeling arguments to develop bilateral coupling between the astrocytic and neuronal compartments of the model.
Furthermore, post-translationally modified forms of Elk-1 are also present in extranuclear neuronal compartments [8].
The neural homeostasis in synaptic patterns and among neuronal compartments improves spike encoding [22], [23].
The transcription factor Elk-1 resides in both nuclear and extranuclear neuronal compartments.
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