Sentence examples for multiple mutations which from inspiring English sources

Although some single point mutations are sufficient to render HIV resistant to individual drugs, escape from combination regimens requires accumulation of multiple mutations, which often appear in specific patterns.

The most likely SMT explanation is multiple mutations, which is inconsistent with the generally accepted view that mutations are rare.

The mutations detected within the sequences of the heat tolerant plaques reveal that there are multiple mutations which are associated with the response to temperature.

PROBLEM: Recent genetic studies link multiple mutations which impair various steps in RNA metabolism to familial neurodegenerative disease, but the great majority of patients are defined as sporadic, without any known mutation as a cause.

Sites with only one mutation in a particular order are more likely to represent a true source-gene mutation than sites with multiple mutations, which probably consist of a combination of source-gene and post-insertion mutations.

Recent experiments in microbes typically have found evidence for multiple novel mutations, which are usually fixed.

As the analysis considers relative enrichment rather than absolute signal strength, functional patterns can be discerned in the presence of multiple spurious mutations, which are referred to as passengers.

Carcinogenesis is a complex process involving multiple sequential mutations, which occur randomly in the DNA of normal cells over many years, even decades, until finally specific genes are mutated and cell growth becomes out of control resulting in the full neoplastic phenotype and often metastasis.

The idea of NEA when applied to cancer-related genes is that multiple key mutations (which are believed to be common in cancer genomes) could alter normal cellular programs for proliferation, differentiation, cell death, and so on, sometimes even producing quasi-pathways [ 9].

Our results also showed that the fitness advantages provided by the substitutions assayed were of different magnitude (Tables  4 and 5), which is in disagreement with the proposal of the multiple mutations model which posits a single characteristic value for the coefficient of selection of all beneficial mutations [ 17, 18].

This technology also has the capability to correct multiple mutations simultaneously, which will be crucial to curing diseases that arise by more than one genetic mutation.