HEases, however, do not have stringently-defined recognition sequences and they usually tolerate single or even multiple base changes, which allows them for invading different alleles in the same genome and perhaps in other genomes [ 4].
In conclusion, our data indicate that the presence of high levels of GST pi transcripts in invasive cancers may be a consequence of the multiple biochemical changes which accompany cervical carcinogenesis.
The development and progression of breast cancer is the result of multiple genetic changes, which lead to complex alterations in signal transduction networks in breast cancer cells relative to their normal epithelial counterparts.
Grade 0 has no or occasional punctate white matter changes and grade 1 has multiple punctate white matter changes, which can be seen in all ages and is common in patients older than 65 years of age.
Mankind faces multiple anthropogenic global environmental changes, which are now large enough to exceed the bounds of natural variability [1], [2].
The results obtained are consistent with transporters undergoing multiple substrate-induced conformational changes, which allow interaction with different accessory proteins to trigger specific downstream events.
This disease is also highly variable with multiple heterogeneous genetic and epigenetic changes which makes it ideal to study cancer by integrating data from multiple experiments to understand its causes at the cellular level.
The development of diabetic cardiomyopathy is most likely induced by a range of systemic changes, which through multiple signaling pathways will lead to functional and structural derangements (Fig. 1).
In addition, this study provides evidences for ploidy level changes, which supports multiple origins via hybridization combined with polyploidy as the most likely scenario although one specimen (no. 119) of Platygyria was found to be probably a diploid (see Figures 6).
