Sentence examples for multiple mutations was from inspiring English sources

In this study, the bacterial laccase gene (cueO) with single or multiple mutations was directly cloned based on the metagenome of a chemical plant sludge.

A UCS2 allele containing multiple mutations was generated in a PCR containing 0.1 mM MnCl2 and 2.4 mM MgCl2.

Mutant clones can acquire additional mutations and the sequential evolution of clones with multiple mutations was observed in primary, secondary, and tertiary clones within the pre-malignant HSC compartment of acute myeloid leukemia (AML) patients (Jan et al., 2012).

When we used a less restrictive approach to character definition in which the requirement of multiple mutations was lifted (RGC_CAs), a weak, although statistically significant trend of the same direction was detected.

Because the occurrence of multiple mutations in ARVC has been reported, the DNA of another 38 consecutive and unrelated patients with desmosomal gene mutations (11 in the PKP2 gene, 13 in the DSP gene, 7 in the DSG2 gene, 2 in the DSC2 gene, and 5 carrying multiple mutations) was investigated for DES mutations.

An additional driver gene mutation increases a cell's fitness by a factor of (1 +s d ), whereas an additional housekeeper gene mutation decreases fitness by a factor of (1 −s h ) and the effect of multiple mutations is multiplicative.

How is change possible where multiple mutations are necessary but intermediate steps have no apparent advantage?

For example, in cavefish, we do not know what is the precise mutation that causes a change in gene expression level, or if multiple mutations are involved.

However, multiple mutations are often deleterious for the activity and the identification of all the residues that historically led to the function is complicated.

Small size, a well-defined structure, and the ability to maintain structural integrity despite multiple mutations are all desirable properties for such designer proteins.

Single mutations on the helix substantially lowered IGH526 binding but did not affect neutralization, indicating either that multiple mutations are required or that additional regions are recognized by the antibody in the context of the membrane-associated envelope oligomer.