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Sequencing evolved receptors revealed that each contained multiple mutations that altered the amino acid sequence.
Coronary artery disease (CAD) is often polygenic due to multiple mutations that contribute small effects to susceptibility.
We also identified multiple mutations that may guide the use of emerging agents.
This presumably reflects the "oncogenic" transformation of the cancer cell lines relative to normal cells, events that reflect the multiple mutations that characterize cancer cells.
Published: February 26 , 2015Cancers develop through the combined action of multiple mutations that are acquired over time (Nowell, 1976).
Imatinib-resistant advanced GIST continues to pose a therapeutic challenge, likely due to the frequent presence of multiple mutations that confer drug resistance.
Similar(38)
Although accounting for up to 8% of human DNA, most of them have acquired multiple genetic mutations that made them harmless, and are usually considered as "junk" DNA.
H1N1/09 viruses appear similar to existing swine lineages, which multiple H2H mutations that may account for its capability to transmit among humans.
In addition, the SHR model is known to have multiple genetic mutations that contribute to the hypertensive phenotype.
For example, multiple gene mutations that result in similar neuroanatomical changes can be filtered, thereby paving the way for elucidation of common/divergent pathways.
Multiple germline mutations that disrupt Bach1 enzyme activity or BRCA1 association have been identified in breast cancer indicating Bach1 is a tumor suppressor [ 89].
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