Sentence examples for numerous mutations that from inspiring English sources

However, the most important problems interpreting mutations is the presence of numerous mutations that have no direct role in cancer; these may be called 'passenger mutations'.

Third, the K562 cell line in particular, being cancer-derived, has numerous mutations that are not reflected in the hg19 assembly.

Here, a hypodiploid ancestor of AA and AB diverged from the H subpopulation for a long period of time, acquiring numerous mutations that are not present in H (AA-AB markers).

The use of whole-exome sequencing, which is employed for analyzing exon regions, has identified numerous mutations that occur in disease, such as BRAF mutations in papillary craniopharyngiomas [ 6] and somatic mutations of BCOR in myeloid leukemia [ 7].

The ratio of resistance to ARV drugs generated from the ViroSeq software (Abbott, USA) showed the presence of numerous mutations that can cause HIV resistances to ARV drugs (Table 6).

Recent work demonstrates that there are numerous mutations that affect phenotypes of waving but not skewing, and vice versa [8 and supplimetal data therein] and a number of these mutants have additional phenotypes that also match the orbital phenotype we observed in this study, like reduced root elongation [ 32, 53].

The results from each of these different technologies have yielded numerous mutations that modify Fc-FcγR interactions and the resultant effector functions (Table 1).

Other mutated genes in breast cancer reported in the Catalogue of Somatic Mutations in Cancer (COSMIC) database [ 60] include PIK3CA (25% [ 61]), TP53 and CDH1 (22%), PTEN (6%), AKT1 (5%) and numerous mutations that occur at frequencies <5%.

We suspect that there will not be an antibody-based test to provide a reliable shortcut to identify tumors that are responsive to PI3K inhibition, and direct detection of the numerous somatic mutations that drive the PI3K pathway will be necessary.

Similarly, the analysis of segregating sites indicated the existence of numerous old mutations that imply the presence of a limited number of common ancestors, which together attest to a more genetically variable past and suggest that the population experienced a bottleneck at some point.

The significance of Aβ is underpinned by the numerous disease-linked mutations that dysregulate APP processing: mutations that result in a spectrum of Aβ peptides with a higher aggregation propensity have been linked to familial AD (Philipson et al., 2010), whereas sequence variation in APP that reduces Aβ production is protective (Jonsson et al., 2012).