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This finding supports the administration of multiple low dose injections of CpG rather than a single high dose injection (Alizadeh et al., 2010).
In chest tomosynthesis, tomographic images are generated from multiple low dose exposures directed towards a stationary digital amorphous silicon flat-panel detector, from tube angles of −17.5° to +17.5° of a moving X-ray tube.
A transgenic mouse line in which NF- κB activation is attenuated specifically in β-cells conferred nearly complete protection against multiple low dose streptozotocin (MLDSTZ -induced T1D.
Multiple low dose exposure of streptozotocin is used in animal studies to induce beta-cell destruction associated with pancreatic insulitis and subsequent T1DM-like symptoms [ 108, 110, 112].
Analysis of multiple low dose challenges in experiments with rodents [ 30] suggested that although repeated doses lead to an increased risk of infection, incubation periods are inconsistent and shorter than expected.
Another frequently used model to induce diabetes in mice is by multiple low dose administrations of the beta-cell specific toxin streptozotocin, where the beta-cells are destroyed and the animals rapidly develop diabetes [ 11].
Similar(53)
A treatment regimen involving multiple low doses of GIDIL2 was more efficacious than a single high dose regimen, resulting in extension of animal survival well beyond the normal 30 day post implantation period typically observed in this aggressive melanoma tumor model.
In fact we have little knowledge on how endothelial cells react to singles high doses of compared to multiple low doses [61].
We also treated mice with fractionated radiation therapy to mimic the clinical situation in which patients are treated with multiple low doses.
A single low dose caused a 3-fold increase, a single high dose or multiple low doses a 6-fold increase.
In mice, however, multiple low doses (40 mg/kg) are the most effective at maintaining mouse viability and inducing pancreatic dysfunction in part through immune destruction.
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