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We exploit the concept of using hydrogen bonds to link multiple ligands for maintaining simultaneous interactions with polyvalent binding sites.
Potential for development of multiple ligands for dopamine receptors involved in numerous neurological disorders was comprehensively reported by Butini et al. [61].
A rational explanation for the existence of multiple ligands for a single activating receptor NKG2D is still lacking.
Comprehensive SSR surveys of odorant receptor activities identified multiple ligands for the Or7a receptor (Hallem and Carlson, 2006).
Here, we developed a method to accurately assess the relative affinity of multiple ligands for a specific protein.
Polymers can be used to carry multiple ligands for cancer targeting and imaging molecules for cancer diagnostics with a simple conjugation-based structural modification [ 101].
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Targeting multiple ligands of TGF-beta family will be more promising as adjuvant therapies for DMD.
Even if the presence of a patchy designer coat on a NP surface is not needed for a particular application, NP bioconjugation experiments frequently proceed with multiple ligands, one or more for targeting and one or more for biocompatibility.
To date, while multiple ligands have been identified for ErbB1, ErbB3 and ErbB4, no ligand is known for ErbB2, although the receptor itself was discovered nearly 30 years ago.
While in some cases this has been adequate, the use of multiple ligands may be required for the successful engineering of some tissue types.
ITGAM (CD11b, Mac-1) encodes the α-chain of αMβ2-integrin (CD11b/CD18 or CR3), a cell surface receptor for multiple ligands, such as complement 3 cleavage fragment and intercellular adhesion molecule-1 (ICAM-1) [13].
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