Sentence examples for multiple joint sites from inspiring English sources

The primary goal of the GARP study is the identification of genetic susceptibility determinants to OA and disease progression in middle-aged sibling pairs with OA at multiple joint sites.

Probands (ages 40 70 years) and their siblings had OA at multiple joint sites of the hand or in two or more of the following joint sites: hand, spine (cervical or lumbar), knee or hip as described previously.

Magnetic resonance (MR) images of the knee were obtained from 182 patients (20% male; aged 43 76 years; mean age 59 years) who had been diagnosed with familial symptomatic OA at multiple joint sites.

Therefore, our aim was to apply factor analytic methods to radiographic OA (rOA) grades across multiple joint sites, representing both presence and severity, to quantify the burden of rOA.

We were therefore interested in applying factor analytic methods to Kellgren-Lawrence global (KL, 0 to 4) and Burnett atlas joint features (0 to 3) radiographic grades [ 22, 23] across multiple joint sites as a way to formulate composite scores of multi-joint rOA, encompassing both presence and severity, using data from participants in the Johnston County Osteoarthritis Project (JoCo OA).

Especially, since pain at multiple joint sites is associated with lower levels of functioning [ 21, 23, 59- 61], more pain [ 21, 23, 59, 60] and higher levels of distress [ 21, 59, 62], and complaints rather than radiographic OA are the main motivation for patients to engage in therapy.

Taken together with our previous findings at the hip joint, this suggests that HBM individuals have a predisposition to a bone-forming phenotype of OA affecting multiple weight-bearing joint sites.

Finally, sex differences in the genetics of OA have been noted for multiple genes and joint sites [ 72- 74], and studies of sex differences in these genetic effects should dovetail with those using advanced imaging and biochemical biomarkers for maximal mechanistic insight.

Because levels of serum biochemical markers for arthritis depend on the circulating concentrations of molecules derived from the affected joints, the marker level is expected to be higher in patients with multiple joint involvement than in patients with a specific joint site.

This lack of an accepted definition makes it difficult to quantify the effect of multiple joint involvement on OA outcomes, leading to the common practice of focusing on a single joint site without considering the contribution of other involved sites.

HU at different bone sites and NBF features at the different joint sites were analyzed by repeated measures analysis of variance (ANOVA) with Tukey's multiple comparison post hoc test.