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HAPLIN is an extension of the log-linear model from a single locus to loci with multiple haplotypes with unknown phase (Gjessing and Lie 2005).
Each spawning group contains multiple haplotypes, with Lake Erie having the most (O P) and Lake of the Woods (C), St . Louis River(F), Moon/Musquash Rivers (L), Lac Mistassini (V), and North River (Y) having the least.
hypogaea) showed a fixed mtDNA genotype (the latter in the only two available individuals examined), but all other surface localities or lava tubes in which Palmorchestia was sampled rendered multiple haplotypes with a remarkably high rate of nucleotide variation.
This is due in part to the difficulty in obtaining consistent information for multiple haplotypes with some of the primer pairs used (which were excluded from the SNP panel).
On the basis of our finding of multiple haplotypes with extreme REHH and at relatively low frequencies (i.e. all below 37%), our results appear to be more consistent with a mode of recent evolution characterized by multiple soft sweeps as opposed to single hard sweeps [ 16].They also suggest that the patterns of differentiation and REHH are not uniform and homogenous across all Eurasians.
Similar(55)
Sequence data further supports the presence of multiple haplotypes within individuals with nine distinct sequences representing 10 clones in 'Amakihi 6, seven distinct sequences representing 10 clones in 'Amakihi 11 and four distinct sequences representing four clones in 'Amakihi 9 (see Figure 3).
The difference in genetic diversity may indicate that California was invaded by LBAM multiple times or once with multiple haplotypes.
The selected allele therefore must have been at a high enough frequency to survive population bottlenecks during human migrations, but also at a low enough frequency so that it did not become associated with multiple haplotypes during the selection phase, thereby reducing or even eliminating the signature of selection [35], [50] [52].
Of the 14 macrofossils with multiple haplotypes, 9 (64%) contained a mixture of the "correct" sequence and sequences that differed from this "correct" sequence by a single transition.
The extent of diversity missed by RFLP analyses is clearly demonstrated by phylogenetic network analyses of sequences with multiple haplotypes found which were initially all assigned by RFLP as haplotype 77.
We also tested this prediction with a logistic regression on the probability of multiple haplotypes in one sample extract with bulk sediment vs. macrofossil and the number of PCR attempts as explanatory variables.
Related(20)
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