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Sequence analysis based on custom resequencing microarrays has recently emerged as a powerful strategy for screening mutations in multiple genes linked to a common phenotype [14] [16].
Our approach suggests a new picture of how variation in multiple genes linked in functional pathways contributes to inflammatory disease susceptibility and provides a useful tool to reveal the hidden information of GWAS that would be missed in single SNP analysis.
Multiple genes linked to innate immune function also have been linked to the risk for alcoholism (see figure 3).
Studies of multiple genes linked to BMP signaling further corroborate the central role of this signaling pathway in lens placode induction.
The up-regulation of METAP2 and the decrease of multiple genes linked to mRNA and protein synthesis in models of competence highlight the importance of de novo protein synthesis and its regulation for successful oocyte maturation and subsequent development.
Breast cancer metastasis suppressor 1 (Bregulatesulatexpressioniof of multiple genes linked to metastasis, including osteopontin (OPN), urokinase-type plasminogen activator (uPA), epidermal growth factor receptor (EGFR), fascin, and connexins [ 108].
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Multiple tumor suppressive genes linked to sporadic tumors have been identified.
Finally, we observed linkage between all three traits and the chromosome 8 region found to be linked to TB in a whole genome scan in a Moroccan population [30]; our results suggest that this region may contain multiple genes each linked to the different stages of the natural history of Mtb infection and disease, or one gene with pleiotropic effects.
Therefore, if multiple genes were linked to a reaction by EHMN and KEGG, they are connected by a comma.
Similarly, KEGG and Reactome contain genes linked to multiple Ensembl Gene IDs.
The co-regulation analysis identified clusters characterized by many genes linked with multiple connections underlining tight relationships.
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