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By 48 h, a significant number of genes were modulated in the heart, including up-regulation of calcium-binding-related gene expression, and down-regulation of multiple genes related to cell adhesion, formation of the extracellular matrix, and the cell cytoskeleton.
Multiple genes related to cardiovascular function and fatty acid metabolism have changed radically through mutations to permit a high-fat menu without high risk of heart disease, the researchers said.
This suggests that SNPs from multiple genes related to DNA damage repair provide complementary information for characterizing ovarian cancer risk.
Rather than focusing on the largest differences among individual genes, GSEA integrates similar trends in expression levels among multiple genes related to one another (functionally, by co-regulation in previous experiments, by chromosomal location, or by similarity of transcription factor binding domains).
Our results displayed multiple genes related to oogesis (7/33).
Multiple genes related to jasmonic acid (JA) biosynthesis were up-regulated in leaves of transgenic AC2 expressing plants.
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Our identification of multiple genes closely related to the handful of genes that have been reported to date by GWAS studies of psychosis points further to the utility of gene-wide analysis of GWAS data sets.
Multiple genes were related to the regulation and response of the immune system, which may be affected by the higher rearing densities in hatcheries.
The proposed network-driven integrative analytical approach can identify multiple genes significantly related to an OSCC stage; the classification model that is developed with these genes may help to distinguish cancer stages.
In several cases, multiple genes with related immune or blood functions were indicated, and correspondingly the individual was the most extreme for the relevant trait, as documented in Table 1.
It would be of particular interest to establish whether the RTK/RAS signalling pathway might be activated in GC due to multiple concomitant mutations of genes related to RTK/RAS signalling or concomitant gene amplifications also present in only small subsets of GC (Deng et al, 2012).
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