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Research on the pathogenesis of TREDs includes studies on toxic RNA that triggers alternative splicing alteration in numerous genes linked to the clinical symptoms of DM1 [ 12, 13], and studies on toxic poly-Q proteins that impair many cellular functions [ 11].
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This was markedly different from the one-by-one gene modifications of recombinant DNA research, since numerous genes were linked together to create a new genome.
Numerous genes are linked to one or another aspect of cell proliferation, and the expression of many others is perturbed in tumors, which does not necessarily point to an actual role in tumorigenesis.
In the 5 mice exposed at each dose, the researchers found numerous dose-dependent alterations in genes linked with liver function.
Transcriptional profiling of ssdp mutant wing discs identified numerous negatively-regulated SSDP target genes linked to Apterous and Pannier binding sites (Bronstein et al., 2010).
Indeed, both transcriptomic (Fig. 2A) and functional genetic (Fig. 4A) analyses identified numerous additional candidate lipid metabolism-associated genes linked to FHV RNA replication.
One of those is DeCode Genetics, which has regularly made headlines for discovering genes linked to cancer, heart attacks and numerous other diseases.
Probes based on sequences of MFLP-derived markers are not suitable for positional cloning of genes linked to the particular markers, because they hybridize to numerous loci throughout a genome.
As expected, genes linked to immune and inflammatory responses are expressed more strongly in ischemic tissue; however, numerous genes and pathways not previously linked with ischemia are also identified.
Or, to go one step further, should we edit genes linked to disease?
Unexpectedly, the researchers also found convergence in many genes linked to vision.
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