Sentence examples for multiple epithelial and from inspiring English sources

These phenotypes suggest a critical role for TAp63 in the maintenance of adult stem cells in multiple epithelial and non-epithelial tissues.

Decreased expression of TJs such as ZO-1 and claudin-4 has been found to play a key role in multiple epithelial and endothelial injuries characterized by high permeability [ 32, 33].

Together, these data demonstrate that c-Myc function is required for DNA damage-induced apoptosis in multiple epithelial and lymphoid tissues, strongly suggesting that it is a general mediator of apoptosis in vivo.

Our findings suggest the hypothesis that autoimmunity triggered by TAAs may inflict epithelial damage to the breast, promoting chronic inflammation and cancer progression; i.e., that BC may behave as an organ-specific AD triggered by multiple epithelial and other breast antigens.

Keratin K5 promoter-induced overexpression of Smad7 specifically in mouse epidermis shows multiple epithelial and developmental abnormalities at birth, exhibited as corneal defects in the eyes, aberrant hair follicle morphogenesis in the skin, epidermal hyperproliferation in the digestive tract and severe thymic atrophy [ 16, 56].

This well-studied transcriptional co-activator is a putative tumor suppressor in multiple epithelial tumors and is part of a t(8 22)(p11 q13) translocation in acute myeloid leukemias (AML) [49].

EP156T cells were strikingly reprogrammed during EMT with loss of multiple epithelial markers and gain of mesenchymal features.

Since TGF-β/Smad signaling is a major anti-proliferative pathway in multiple epithelial cell types, and is active in the postnatal mouse bronchiolar epithelium [34], we tested the effect of Sox2 on TGF-β1/Smad3 mediated gene transcription.

The large intestine, from which HT-29 cells are derived, is composed of multiple epithelial cell types, and we used confocal microscopy to assess if any of these cell types are present in our 3-D aggregates and if Salmonella is targeting these cell types during infection [58].

TEBs were characterized by location within the gland, presence of multiple epithelial cell layers, and direct apposition of epithelium to adipocytes without extracellular matrix.

While epithelial cells in the mature lung are normally quiescent, subpopulations of endogenous cells within the respiratory epithelium possess the capacity to reenter the cell cycle, proliferate, and redifferentiate into multiple epithelial cell types with appropriate function and location along the proximal/distal lung axis following injury.