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The expression of c-MET has been studied in many epithelial and mesenchymal cancers.
ABP1 encodes a membrane glycoprotein that is expressed in many epithelial and haematopoietic tissues.
Progranulin, also known as acrogranin, proepithelin and PC cell derived-growth factor, is a 68 kDa glycoprotein secreted by many epithelial and immune cells [ 22].
Surprisingly, ablation of the Ink4a gene, which encodes p16Ink4a and p19Arf tumor suppressors and whose deficiency synergizes with ras activation in many epithelial and mesenchymal tissues, failed to accelerate Ha-ras-induced urothelial hyper-proliferation or tumor formation [ 46].
In humans, the tissue distribution of FAT transcripts in fetal and adult tissues has been analyzed in detail by Dunne et al[ 33] who showed that FAT mRNA is present in many epithelial and some endothelial and smooth muscle cells.
In humans, cavin-3 is encoded in the 11p15.5 tumor suppressor locus and loss of cavin-3 expression is common in many epithelial and glial derived cancers (Zochbauer-Muller et al., 2005; Lee et al., 2008; Martinez et al., 2009; Tong et al., 2010; Caren et al., 2011; Lee et al., 2011).
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A study of War-T by Andreadis et al. showed that ICAM-1, a cell adhesion factor, was strongly expressed in the germinal center of folliculus lymphaticus and moderately expressed in many epithelial cells and more specifically on the whole membrane of basaloid cells and the luminal surface of columnar cells [ 8].
The EGFRs/Her1/ErbB1 receive this attention due to their abnormal expression in many epithelial tumours and their influence on the growth and survival in malignant states.
Cox-2 may have a role in the carcinogenesis of many epithelial cancers, and expression levels have been linked to tumor invasiveness and angiogenesis [14].
The expression or activation of human growth factor receptors are altered in many epithelial tumours and clinical studies indicate that they have important roles in tumour aetiology and progression.
The integrin αvβ6 occurs in many epithelial tumors and has been considered to play a prominent role in tumor invasion and metastasis [ 14].
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