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We describe the use of multiple endpoints in the design, analysis, and interpretation of pain clinical trials, and review available strategies and methods for addressing multiplicity.
Differences in assay characteristics highlight the need to examine multiple endpoints in the absence of a clear correlate of vaccine-induced immunity to HIV-infection or disease progression.
Because the protocols for nuclear staining are well established, we focus on delineating nuclear regions, which also provides context for quantifying multiple endpoints in high content screening.
We used the conditional probability function suggested as a method for summarizing multiple endpoints in the competing-risks setting by Pepe [ 33].
Because of the multiple benefits of increased physical activity and the different level of benefit any physical activity intervention can have, physical activity trials should be evaluated using multiple endpoints in a continuous fashion (very beneficial, beneficial, moderately beneficial, not beneficial, moderately harmful, etc).
In the absence of suitable rules, examples are readily found of investigators setting a primary endpoint of response, a drug failing to meet that response, but the drug being declared interesting for further study based on other desirable characteristics [ 18, 19] Other authors have investigated the use of multiple endpoints in phase II trials.
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In considering the significance of trends in FA levels with longevity, strict Bonferroni adjustment for multiple endpoints shown in Table 2 would require P < 0.05/21, or 0.0024.
Given the multiple endpoints measured in the study, the sample size was calculated according to the BBT, that is, to the parameter expected to benefit the most from the experimental treatment.
Testing of multiple endpoints (changes in the last 6-hour mean ambulatory SBP and DBP) utilized a pre-defined hierarchical testing procedure in the following order: (1) comparison of treatment groups based on SBP; and (2) if significant, comparison based on DBP.
Frequencies for specific risk factors by endpoint are presented in Table 2. Reference numbers for the papers examining each risk factor for each endpoint are provided in Table 3. * Papers that reported on multiple endpoints are included in each of the relevant columns.
Studies that evaluated multiple endpoints were included in each study endpoint category.
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