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It may be prudent to investigate the kinetics of adduct loss following subchronic oral BaP exposures in order to validate the efficacy of simultaneous measurements of numerous endpoints in the same animals.
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Hatchlings were raised for 13 months during which numerous endpoints were measured.
Plant hormetic dose responses were observed for numerous endpoints including disease incidence, reproductive indices, mutagenic endpoints, various metabolic parameters, developmental processes, and a range of growth indicators.
Although this was a single-centre, phase I study in a limited number of patients and with relatively brief follow-up, it showed that this innovative treatment was not only safe and well tolerated in patients with SSc but also provided encouraging preliminary evidence of efficacy in numerous secondary endpoints.
How do they find paths between endpoints in these networks?
Therefore, there are endpoints in.
Surrogate measures served as primary endpoints in 119 trials (94.0%).
All examined endpoints were significantly altered by the mixture albeit with great variability between endpoints in the sensitivity.
"We need to study these endpoints in relation to DINP as well". .
The Seattle Angina Questionnaire (SAQ) [ 3] is a coronary disease-specific patient reported outcome measure (PROM) that has been included as a key endpoint in numerous clinical trials of stable coronary disease [ 4- 9].
Since then, radiation-induced bystander effects (RIBE) have been demonstrated in numerous in vitro and in vivo studies using a variety of biological endpoints (reviewed in Prise and O'Sullivan, 2009).
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