Aplidin clearly demonstrated activity against the various endpoints evaluated in this model (e.g. paraprotein, BM invasion, angiogenesis and so on).
Data are given in the report for fetuses from 12 individual litters, but it is not clear which litters aborted.> -wrap-foot> > -wrap-foot> totalotal number of litters included in the data evaluation for various endpoints was not explained in detail in the report and appear to be different for different endpoints.
In an effort to develop a shorter term approach, the early responses of various endpoints were evaluated in Xenopus laevis throughout 8 d of exposure to three TH synthesis inhibitors: methimazole (100 mg/L), 6-propylthiouracil (6-PTU) (20 mg/L), and perchlorate (4 mg/L).
A large part of the EDC debate is on the various endpoints that have been used in studies to assess chemical effects.
In this study, we jointly assessed – during the same time period and at the same site – various endpoints of male reproductive function in humans and wild mammals, both chronically exposed to pesticides.
To explore whether the trans8_eQTL signature influences these traits we looked at the relationship between the expression of genes in the signature in adipose tissue and various endpoints.
The effects of CuNMs in enchytraeids are well reported in the literature, assessing various endpoints, covering survival, reproduction16, 17, avoidance behaviour16, cellular energy allocation18 and oxidative stress19.
Various endpoints for MT have been described in the literature, ranging from the start of pressure increase (e.g. [ 20, 22]), 100 N on the brake pedal [ 3, 23], up to a minimum of 200 N being applied on the pedal [ 24, 25].
The outcome data collected in the registry was missing various endpoints for patients, though multiple attempts were made to collect outcomes for each time point.
