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Exact(5)
To better measure the overall impact of the intervention, individual endpoints as well as a global test of multiple endpoints are used.
In sum, cohorts are complex and most informative when exposures are updated or multiple endpoints are addressed.
When multiple endpoints are of interest in evidence synthesis, a multivariate meta-analysis can jointly synthesise those endpoints and utilise their correlation.
Furthermore, when multiple endpoints are addressed, they can place etiology and prevention in broad public health context giving insights to the trades-offs of risks and benefits of lifestyle and lifestyle changes.
Frequencies for specific risk factors by endpoint are presented in Table 2. Reference numbers for the papers examining each risk factor for each endpoint are provided in Table 3. * Papers that reported on multiple endpoints are included in each of the relevant columns.
Similar(55)
Studies that evaluated multiple endpoints were included in each study endpoint category.
No adjustment to multiple endpoints was performed due to the exploratory character.
No correction for multiple endpoints was made for either of the analyses.
In the few cases in which multiple endpoints were used, they were not evaluated in the same subject.
Since multiple endpoints were tested individually (rather than a single significant finding among a family of outcomes used to draw study conclusions), there were no corrections for multiple comparisons [ 33].
Even for studies in which the test material is a single chemical of known purity, interpretation of responses for multiple endpoints is not necessarily straightforward (Lewis et al., 2002).
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