Sentence examples for multiple different mutations from inspiring English sources

More than 50 associated genes have been identified so far, but multiple different mutations within these genes can cause the condition, and there is a long way to go before every mutation is isolated.

These test cases were modeled on the ERBB2IP-1 (Erbb2 interacting protein) wild type protein, each with multiple different mutations.

Finally, it is important to note that, although we consider here the relatively simple case of digenic interactions, more complicated interactions involving multiple different mutations can also give rise to synthetic lethality.

In contrast to some genetic diseases in which one or a small number of mutations account for the diseased condition in majority of patients, HPRT deficiencies are caused by multiple different mutations affecting nearly all parts of HPRT gene.

We interpret the fact that there are similarities in activity profiles despite little sharing of common mutations to indicate that many different mutations can cause similar changes in activity profiles (for example, there are multiple different mutations that preferentially enhance activity on either phenolic ether or fused ring substrates).

There may be multiple different mutations present at low levels in these cells which act together to produce the biochemical defect (Trifunovic and Larsson, 2008), or there may be dominant mtDNA mutations which cause a biochemical defect at low mutation levels (Sacconi et al., 2008).

Similarly, the above coat color mutations also highlight how the same gene may be subject to multiple different causal mutations.

These studies support the notion that pro-inflammatory pathways can be regulated by multiple different driver mutations in PDAC.

In conclusion, our data show FASN inhibition inhibits xenograft tumor growth in K-Ras-mutant and wild-type tumor models as well as tumors from multiple different diseases with mutations in other commonly mutated or over-expressed oncogenes.

Until recently, NF1 patients were clinically diagnosed [ 19] with few undergoing mutation screening as the NF1 gene spans 300 kb and is composed of 58 exons, with multiple different and complex mutations identified in the limited numbers of cases studied.

Furthermore, the presence of multiple different ICP2 resistance mutations within this single host suggests that selection of phage resistance occurred multiple, independent times during the course of infection.