Multiple different transcript variants were found for the human VDR.
Alternative splicing results in multiple different CD44 variants with a diverse functional repertoire.
It is expected that multiple different causal variants of low frequency will be found to reside within the same functional units, and that different alleles will be carried by different individuals across studies.
While the i-PITT can be used for generating any type of transgenic mice, this technology will be particularly suitable for simultaneously generating Tg lines for multiple different polymorphic variants or mutant forms of a gene.
There exist several algorithms for unsupervised learning that are based on probabilistic reasoning, such as Bayes networks, graphical models, multiple eigenspaces, and different variants of HMMs.
Many AM fungi are difficult to identify using exclusively either morphological characteristics or molecular criteria, and they are difficult to culture in the absence of a host plant and possess multiple and slightly different variants of the nuclear-encoded ribosomal RNA gene within single spores (Sanders et al. 1995; Lanfranco et al. 1999).
Until recently, the only gene in which multiple different, but rare variants have been consistently associated with monogenic fatness is the gene of the melanocortin receptor 4 (MC4R) but these mutations are infrequent in the general population [4].
In brief, the motifs are: (i) "index", the most prevalent sequence; (ii) "major" variant, the second most common sequence and the single most prevalent variant of the index, with at least one amino acid mutation; (iii) "minor" variants, multiple different sequences, each with an incidence (percent occurrence) less than that of the major variant; and (iv) "unique" variants, each observed only once.
Veridical is able to automatically process variants from multiple different experimental samples, and can group the variant information if any given mutation is present in more than one sample.
This organization in tandem arrays of R-genes provides a broader potential range of responses to multiple pathogens and to different variants of the same pathogen [ 9].
