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To demonstrate the versatility of the proposed method in application to multiple datasets, the Wasserstein metric is applied to a series of different simulations that were contributed to the TNF-workshop.

For more complex dynamic experiments, for instance those that produce single HDF5 files with multiple datasets, the current GUI is not adequate and reconstruction via command line is still necessary.

With the used of multiple datasets the experimental results demonstrate that the application of our method as a post-processing step greatly increases the quality of the prediction of Fpocket and ConCavity, two state of the art protein-ligand binding site prediction algorithms.

When comparing multiple datasets, the Ratio filtering test must be satisfied in all datasets for a given gene to be selected.

The method we proposed is highly effective in generating quality gene signature through multiple datasets; the publication of the combined CRC gene signature and the list of candidate compounds from this work will benefit both cancer and systems biology research communities for further development and investigations.

When there is no linear correlation between a gene pair in any of the multiple datasets, the above chi-square statistics follows a central chi-square distribution with degrees of freedom 2n and hence the p-value for meta-analysis can be obtained by (17) where is a chi-square random variable with 2n degrees of freedom.

Similar(54)

To study the effect of multiple datasets on the quality of the inferred networks, we have used four datasets in each experiment.

By combing the differential expression profiles from multiple datasets and the NOT2D network, the top 5 scoring active modules were identified in the obesity samples as well as in T2D.

For each cancer type, we then computed representative P values of the genes as the combined P values of the genes in multiple datasets of the cancer type (19) using Stouffer's method (Materials and Methods).

The likelihood that a frequent co-splicing cluster is biologically meaningful increases with its recurrence across multiple datasets, highlighting the importance of the integrative approach.

We demonstrate that the likelihood for an exon cluster to be biologically meaningful increases with its recurrence across multiple datasets, highlighting the benefit of the integrative approach.

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