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As shown in Fig. 2C, cells with an integrated allele of chk1D469G behave much like cells with a disrupted copy of chk1 demonstrating that only in multiple copies is the Chk1D469G protein capable of function.

The pt genome, in multiple copies, is inherited in a non-Mendelian fashion.

b The ratio of single to multiple copies is the number of paralogs having one copy versus the total number of paralogs with two and three copies.

We hypothesize that in the presence of fusion-mediated complementation, the redundancy inherent in multiple copies is sufficient to permit relatively normal mitochondrial function even without autophagy.

These organelles have retained their own genome (mtDNA) in most species, which is present in multiple copies, is often maternally inherited, and in man (the focus of this review) is approximately 16.5 kb [1,2].

Subsequently, each derivative chromosome, represented by one (Gribble et al., 2004) or generally multiple copies, is amplified using DOP-PCR or commercially available whole-genome amplification kits to provide sufficient DNA.

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Similar(53)

Multiple copies were then routed to multiple record centers.

Multiple copies are held at one or more data centers.

With the exception of the TATA box, only those with multiple copies were counted.

The integration of multiple copies was confirmed by genomic Southern blot analysis.

These multiple copies are often colocalized in interphase, suggesting either an ectopic association or a highly reproducible interphase chromatin configuration.

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