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Exact(6)
Also, these algorithms need much longer sequence for reliable synchronization.
First, the sequence determinants of origin function seem to spread out over a much longer sequence.
In particular, semi-global alignments attempt to infer homology between an entire short sequence (the query sequence) and some portion of a much longer sequence (the subject sequence).
As a result, KMD1B binds to a much longer sequence of histone H3 than KDM1A, and its activity requires engagement with both substrate and non-substrate regions of the histone tail through different protein domains.
However, whereas ARS activity can be predicted almost perfectly using a 50 bp ACS motif in K. lactis and with fairly high accuracy using a 33 bp ACS motif in S. cerevisiae, ARS activity in L. kluyveri seems to be determined by a much longer sequence that includes the 9 bp ACS.
However, given that this analysis is based only on the 9 bp ACS and that the replication sequence determinants in L. kluyveri extend over a much longer sequence, the relatively small difference in selectivity between the L. kluyveri and S. cerevisiae ACS cannot fully explain the large difference in their acceptance rates of foreign ARSs (Additional File 1, Table S4).
Similar(54)
Today, third generation sequencing platforms are entering the markets and bringing a new wave of discoveries as they allow a much longer sequencing read than the second generation platforms.
In stark contrast, a similar plot of an 8 Mb large section of human chr. 1 between 24 Mb and 32 Mb, displayed numerous much longer sequences, including 76 which were between 50 and 269 bases long (Fig. 1b).
MetaCluster-TA generates much longer sequences to do alignment, and the alignment result is supposed to be more accurate.
All the GCAT benchmarks contain sequences much longer than the 36bp single ended sequences on which Bowtie2 G P was optimised, nevertheless both GP versions do well on the much longer sequences.
This inability reflects the requirement of the FFP method to use much longer sequences in order to capture the phylogenetic relationship among phages.
Related(17)
substantially longer sequence
much less sequence
much smaller sequence
much larger sequence
much better sequence
much longer shelf
much higher sequence
much lower sequence
much thicker sequence
much longer time
much longer runway
much wider sequence
much longer nobody
much more sequence
much shorter sequence
much stronger sequence
much greater sequence
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