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We used the DBA ho-4j strain of the hotfoot mouse, which carries a 170-amino acid deletion of the N-terminal region of GluRδ2 [23] [23].
Using the Rpe65R91W/R91W mouse, which carries a mutation in the Rpe65 gene leading to progressive photoreceptor degeneration in both patients and mice, we defined stages of retinal degeneration that still allow cone rescue.
In this respect, it should be recalled that the diminuendo mouse, which carries a mutant miR-96 seed region, does not have a major effect on miR-96 expression levels (15).
To better understand the genotype and phenotype relationships, several mouse models have been developed, including the transchromosomic Tc1 mouse, which carries an almost complete human chromosome 21, that displays several locomotor and cognitive alterations related to DS.
As the Fbxw7 null mutant mice do not faithfully recapitulate the mutations most commonly present in human cancers, we have generated a conditional Fbxw7 mutant mouse which carries one of the most commonly occurring propellor tip missense mutations.
The heterozygous TSK-1 mouse, which carries a 30- to 40-kb genomic duplication in the fibrillin-1 gene, has marked hyperplasia of loose connective tissue around the thoracic aorta [ 30] and altered aortic hemodynamics ex vivo suggestive of endothelial dysfunction [ 31].
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Various C-terminal kinesins (i.e. Ncd in Drosophila and KIFC2 in mouse), which carry their motor domain at the C-terminus, also move specifically toward the minus end.
The eggs were then implanted into female mice, which carried them to term.
Complete loss of Stat3 was observed in islets from mice, which carry two floxed Stat3 alleles and the Pdx1-Cre transgene.
Three years later, in 1996, the researchers reported in Nature that Ames dwarf mice, which carry a mutation in a gene called Prop1, live 50% longer than normal mice.
In addition, a gene of an acceptor can be replaced by the gene of a donor, as in the case of transgenic mice, which carry healthy or malfunctioning human genes.
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