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The need of a cardiac stressor in our mouse model (here: pressure overload by TAC) supports the "second hit" hypothesis in titin-based DCM.
Analogously, several miR-200c binding sites are predicted on Mus musculus ZEB1, ZEB2 and NCAM1 3′UTR, indicating its putative role in the mouse model here presented.
As a necessary first step toward the eventual goal of developing such a mouse model, here we asked whether mammographic density could be altered within the mouse mammary gland.
Along with a previous transgenic mouse model with FPPS overexpression we reported previously [ 11], the transgenic mouse model here provides a new means of studying FPPS gene function in vivo.
In the Brotherton et al. study, which compared sALS cases to an A4V fALS case and controls, C4F6 recognized skein like inclusions (similar to what we observed in the L126Z mouse model here) in the spinal motor neurons of A4V fALS cases.
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Since impaired adult neurogenesis is shown to augment memory deficits in AD mouse models, here we examined the status of adult neurogenesis in AICD transgenic mice.
We therefore examined whether the HCC gene signature identified in the mouse models here is capable of segregating human HCCs of various etiologies.
The dual role in protection and pathology for mast cells revealed in both mouse models here and in our previous studies [3] has implications for human infection as well, as discussed in response to the next question.
Such studies may be facilitated by the CgB-ko mouse model described here.
In the PAM mouse model described here we have also found that the disease incidence and severity decreased with parity.
The LmnaDhe mouse model studied here exhibits physiological phenotypes similar to human progeria and related laminopathies characterized by lipodystrophy, cranial abnormalities, and skin defects [29].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com