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The last project he worked on at the Institute was a study with assistant Margaret Holmes of autoimmune disease in the New Zealand black mouse model; this mouse has a high incidence of spontaneous autoimmune hemolytic anemia.
Applied in a mouse model, this technique enabled the identification of ischemia-reperfusion injury in kidneys and described the 3-dimensional anatomical distribution of inflammation in relation to the renal arterial tree.
Because the effects of the siRNAs on anchorage-independent growth seemed to correlate with their effects on tumor growth in our mouse model, this suggests that growth in soft agar might be an effective method of screening the responsiveness of cells to larger/different panels of siRNAs.
47 In the Foxn1 nu mouse model, this neutrophil response must remain intact to prevent tumor relapse.
As FKBP51 levels were elevated in the PAE mouse model, this indicates that regulatory control is altered in these animals.
In a sepsis-induced AKI mouse model, this particular inhibitor significantly decreased the initial peritubular capillary dysfunction, as well as the subsequent tubular injury [ 59].
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As an anatomical reference for neuroscience research using mouse models, this paper presents DTI based atlases of ex vivo C57BL/6 mouse brains at several developmental stages.
In both mouse models this is associated with a decreased heart weight, likely secondary to a decreased after-load, while heart rate is unchanged.
In mouse models, this has been investigated in the context of invariant natural killer T (iNKT) cells and IgE.
In transgenic mouse models this cytoprotection is brought about both through improvement in muscle function and decreased apoptosis [ 32- 34].
The disease onset is much later than many other tg SOD1-ALS mouse models, this is appropriate for evaluating any potential modifying effect of SOD1 loss of function.
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