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The long retention of these ligands in the normal mouse brain suggests that there may be high binding for these probes in the brain not associated with Aβ plaques.
The finding of unusually high amounts of PrPres in neoplastic lymphoreticular tissues of vCJD mice, in a range comparable to that of the human and mouse brain, suggests that rapidly growing lymphoreticular tumors accumulate PrPres at a high rate.
Thus, an inverse correlation between RanBP9 and spinophilin, which is a marker of spines in different regions of mouse brain, suggests loss of spines may be at least partially due to RanBP9.
For the purpose of this study, and due to the limitations involved in acquiring high quality human DNA, we have classified the brain as a single tissue, although results from analysis of the mouse brain suggests there may be region dependant parent-of-origin specific expression [ 33].
In support of the latter, the high frequency at which guanine persists in isolate D1 when switching from three passages in BHK-21 cell culture to one passage in mouse brain suggests that the presence of guanine and the associated amino acid change to valine in the envelope protein confers elevated fitness in BHK-21 cell culture.
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Moreover, indicators of altered osmoregulation in Mecp2-null mouse brain suggest another link to changes in brain size, potentially caused by neurons and astrocytes.
In conclusion, we found a large number of protein expression differences throughout the entire lifespan of APP23 mice, beginning at ED16, a phase where neurogenesis is predominant in the developing mouse brain suggesting an early impact of transgenic APP.
Early studies on mouse brain suggested that there are between ~10,000 [ 18] and ~100,000 [ 41] transcript species per cell.
Furthermore, this interaction occurs at the synapse and is particularly evidence in adult mouse brain suggesting a role in synaptic plasticity.
Satb1 was identified in our genome-wide microarray screen as a gene downregulated in Lhx6-deficient mouse brain, suggesting that its expression depends on Lhx6 activity.
Our in situ hybridization shows that SLC17A9 mRNA is widely expressed in the mouse brain, suggesting that neurons from most brain regions may have the capacity to store ATP in vesicles.
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