At least 27 alternatively spliced NCAM mRNAs are present in rat brain, suggesting wide and diverse functions of NCAM (Reyes et al., 1991).
Membrane binding and autoradiographic studies on rat brain suggest the existence of polyphenol specific plasma membrane binding sites, possibly underlying the neuroprotective action of polyphenols [21].
These data are in agreement with previous studies in the aged rat brain suggesting a rostral caudal gradient of microglial activation (Kullberg et al., 2001).
Furthermore, transplantation of glioblastoma cells expressing Rac, CDC42, or RHOA reporters into rat brain suggested that the balance of Rac, CDC42, and RHOA activities dictates modes of cancer cell invasion (Hirata et al., 2012).
Indeed, our initial investigations of follistatin expression by the NPCs after transplantation to the rat brain suggest that they sustain the follistatin expression in vivo (K. Staflin, unpublished observation).
Previously, heavy non-CpG methylation in zebrafish was reported ; however, other bisulfite sequencing experiments have demonstrated very low levels of non-CpG methylation.,, RRBS studies on rat brain suggested less than 1% non-CpG methylation.
The creatine transporter is widely expressed in the fetal rat brain, suggesting that the immature brain may have a greater capacity to take up creatine from the circulation compared to the more mature brain, although evidence also suggests that creatine may enter the immature brain more easily by diffusion - i.e., a non-carrier pathway [ 93].
Although the resolution and sensitivity of RatCAP was comparable to the commercial scanner, co-author Daniela Schulz, a behavioral neuroscientist, says RatCAP provided a different pattern of dopamine activity in the rats' brains, suggesting that anesthesia may alter neurochemistry more than researchers had realized.
Although the precise relationship between increased activities of PKB/Akt and ERK1/2 by aging and decreased expression of Gβ4 remains unknown, current data represent the first demonstration of a change in Gβ4 expression with age in rat brain and suggest that an age-related alteration in expression level of Gβ4 may, at least in part, play an important role in aging processes.
The expression and function of the MAMDC1 gene and protein are not well studied: besides showing expression in the rat brain and suggested to have a role in axon guidance [28], not much is known.
