Affinity purification of PSD-95 (DLG4), a membrane-bound kinase from mouse brain, allowed the identification of physically associated synaptic protein complexes that had been previously linked to schizophrenia and other diseases [ 59].
In utero electroporation (IUE) of the bicistronic plasmid pCAG::PLE-IRES-mCherry into the developing mouse brain allowed PLE and mCherry co-expression in only a subset of cortical layer 2/3 pyramidal neurons.
Soon, high-resolution images ought to be available in the Mouse Brain Library, allowing cell-by-cell resolution that would open up a new realm to student exploration of the relationship of brain phenotypes to genotypes.
In experimental gliomas, OCT discriminated the growth pattern of invasive and non-invasive tumors in mouse brain and allowed the multiplanar reconstruction of the tumor/brain interface by three-dimensional reconstruction of OCT image stacks [ 7].
The former technique allows mouse brain reconstruction with high contrast and resolution in 3D, but imaging time can reach even 1 month for a single brain (Gong et al., 2013).
We report the development and characterisation of an ex vivo slice culture system using mouse brain and spinal cord, allowing investigation of myelination, demyelination and remyelination, which can be used as an initial reliable screen to select the most promising remyelination strategies.
To establish a high-throughput quantification system, PrP derived from two mouse-adapted scrapie prion strains, RML and ME7, was purified from infected C57BL/6 mouse brain by repeated NaCl precipitation allowing recovery of 97% of the total PrPSc[ 16].
Harvard recruited Dr. Lichtman to push the connectome quest to its limits by tackling an entire mouse brain at the finest scale and allowed him to set up his own connectome research laboratory, staffed with four other people.
Wolf Cocklin @wolfcat on Tony Abbott's decision to "suspend" maritime management plans introduced by the Labor government to allow fishers back into those areas: Mouse brain What thoughts cross the mind of a mouse?
This method also allowed them to calculate that the mouse brain made about 20 new dopamine neurons every day.
