Sentence examples for motor neuron generation from inspiring English sources

This supports an influence of serotonin on motor neuron generation, but not a generalized effect on spinal neurogenesis.

In contrast to motor neuron generation, there was no significant difference in the number of newly generated serotonergic neurons between the rostral and caudal lesioned spinal cord.

The elucidation of the roles of RA in motor neuron generation benefited largely from the use of an ex vivo explant system [9], [21].

In embryos with pharmacologically blocked dopamine signaling, serotonin still promotes motor neuron generation.

Hence, serotonin is present during motor neuron generation, but no cellular source supplying the spinal cord is detectable.

Activation of proliferation in the pMN-like ERG domain caudal to the lesion only is consistent with the rostro-caudal differences in motor neuron generation.

To determine whether increasing the serotonin signal in the absence of a spinal lesion was sufficient to induce motor neuron or serotonergic interneuron generation, we injected unlesioned animals with serotonin in the same way as lesioned animals.

Generation of primary motor neuron cultures was as described previously [ 21, 28], and plasmids containing EGFP-tagged full-length TDP-43 and EGFP-tagged Met-TDP-35 in pEGFP-C2 vector were microinjected at 200 ng/μl into motor neuron nuclei along with 20 μg/μl of the fluorescent marker Dextran FITC (Life Technologies).

Using a modified motor neuron differentiation method, we subsequently generated ISL1+ motor neurons from isogenic iPSC lines and performed genome-wide RNA sequencing (RNA-seq) analysis.

Here, we demonstrate the successful generation of iPSC and further motor neuron differentiation from ALS8 patient cells.

Alternatively, similar to its role during motor neuron differentiation [9] [11], RA may have distinct sequential functions during the generation of β-cells, i.e. inducing both Ngn3 expression and the further differentiation of Ngn3+ cells into β-cells.