Sentence examples for motor neuron differentiation from inspiring English sources

Using a loss-of-function approach, we found that TAF9B is required for the efficient expression of neuronal genes upon in vitro motor neuron differentiation.

10.7554/eLife.02559.007 Figure 4. TAF9B is specifically required for the efficient activation of neuronal gene expression during in vitro motor neuron differentiation.

DOI: http://dx.doi.org/10.7554/eLife.02559.007 10.7554/eLiFigure59.008 Figure 4 figure supplement 1. TAF9B is specifically required for the efficient activation of neuronal gene expression during in vitro motor neuron differentiation.

As seen in other differentiated cell types, several TAFs are down-regulated upon motor neuron differentiation.

Here, we report that the orphan TBP-associated factor TAF9B is selectively up-regulated upon in vitro motor neuron differentiation, and is required for the transcriptional induction of specific neuronal genes, while dispensable for global gene expression in murine ES cells.

The authors report here that the TBP-related factor TAF9B is strongly and selectively induced upon motor neuron differentiation, and is required for the expression of a subset of neuronal-lineage genes.

However, much less is known regarding retrograde mechanisms that control motor neuron survival and presynaptic differentiation.

Taken together, these genes are suggested to be involved in the motor neuron enlargement during soldier differentiation.

A higher percentage (12.5% [de-ATSC] and 8.5% [ATSC]) of motor neuron and MBP-positive myelin differentiation (NF160/CM-Dil double positive) was detected in de-ATSC (2.4 and 3.8% of each engrafted cells) of neural and MBP-positive myelin differentiation in the lesion sites of SCI (Figure 6D).

The final developmental step of cultured myoblasts, without the presence of a motor neuron in vitro, represents the differentiation into myotubes [ 28, 29].

Given that Taf9b KO cells in vitro showed clear de-regulation of genes in both progenitor cells and post-mitotic motor neurons, we surmised that loss of TAF9B in vivo may affect not only motor neuron formation but perhaps also proper differentiation of other cell types present in the spinal cord.