Sentence examples for motif were mutated from inspiring English sources

Competition experiments with unlabeled probes containing mutations of conserved nucleotides showed that Zfp335 binding was abolished when both DNA elements of the bipartite motif were mutated, whereas mutations in either the first or second element had an intermediate effect, indicating that both parts of the consensus motif are required for full Zfp335 binding.

A similar loss of Mad1 localization and checkpoint activity occurred when only the outward-facing amino acids R and K of the RLK motif were mutated or when the C-terminus was truncated (Fig 1).

The interaction between Vangl2 and GST-μ1 was severely reduced when crucial residues of the YYXXF motif were mutated, whereas alanine substitutions of the adjacent dileucine amino acids had no effect.

To abolish ERM binding without affecting the α-actinin binding site, only the first three key residues R, T and Y of the ERM binding motif were mutated to alanines.

It proved difficult to establish stable DT40 cell lines expressing rat IP3R1 in which critical residues within the 1-8-14 1-8-14 1-8-14tated, but we succeeded with two motifts.

The consensus blocks identified the sequences EExxE, ExE or EEx as being found in IDTS (Fig. 3A and B), and the lack of translocation of SidM when Glu residues in this motif were mutated (EETRE) is consistent with it being part of a translocation signal (Fig. 5).

To further understand the specificity of these interactions, the E-box motif was mutated and the interaction between the TFs and the mutated motifs were investigated using yeast one-hybrid analysis.

A peptide nanowire of 33 amino acids, comprised of a leucine zipper motif, was mutated to bind divalent metals, conferring conductivity into the peptide.

Named PTP "substrate-trapping" mutants by the Tonks laboratory, they represent a diverse variety of defective PTPs that are epitomized by the Cys to Ser mutant (C/S) where the active cysteine residue of the signature motif is mutated to a serine residue.

However, when the Sp1 motif was mutated no such Sp1 mediated enhancement in luciferase gene was seen (Figure S3B, compare bar 2 and 3 with bar 1).

Importantly, the lethal effect of D-CblL was significantly reduced when the Drk binding motif was mutated in D-CblL (Table 2).