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Novel C-aryl glucoside SGLT2 inhibitors containing pyridazine motif were designed and synthesized for biological evaluation.
Novel C-aryl glucoside SGLT2 inhibitors containing pyrimidine motif were designed and synthesized for biological evaluation.
Novel C-aryl glucoside SGLT2 inhibitors containing cyclic diarylpolynoid motif were designed and synthesized for biological evaluation.
Three 14-mer macrocyclic peptides 1 3 containing mono-, di- and tri-RGD structure motif were designed and synthesized by sortase A-mediated ligation in good yields.
A series of highly active C-aryl glucoside SGLT2 inhibitors containing a biphenyl motif were designed and synthesized for biological evaluation.
Novel nonpeptide small molecule renin inhibitors bearing an N-isopropyl P1 motif were designed based on initial lead structures 1 and aliskiren (2).
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The S.E.C.'s new site, which features an understated blue and white motif, was designed "in house by talented staff in several offices," according to an agency spokesman, John Nester.
A neutral receptor, integrating a series of –N(H) and –C(H) donor groups organized in a Λ-shape motif was designed and prepared.
A novel conformationally constrained pyridazinone Eag-base PNA-monomer 2 capable of binding thymine in a triplex motif was designed and synthesised.
A series of novel thiol-based histone deacetylase (HDAC) inhibitors bearing 3-phenyl-1H-pyrazole-5-carboxamide scaffold as surface recognition motif was designed, synthesized, and evaluated for their HDAC inhibition activity.
Amphiphile A consisting of a β-alanine oleophobic motif and a pentadecyl oleophilic motif is designed to self-assemble in a continuous rubber phase to form discrete micelle-type structures under high-temperature processing conditions and crystallize upon cooling to form supramolecular reinforcing particles dispersed in the rubber phase.
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