This motif is seen for all fingerprint volume regions and may reflect the relative uniqueness (or lack thereof) of shapes across the first ten diverse conformers in PubChem. Figure 14 Frequency of fingerprint reference shape use.
The travel motif is seen throughout Angelou's series of autobiographies, emphasizing what Lupton describes as Angelou's "continuing journey of the self".
Comparable conservation was seen between protein orthologues containing one or more transmembrane domains with the known di-lysine motif in the last 25 residues and elevated conservation of the XDEL motif was seen in luminal proteins (Figure 8A and 8B).
From this differential comparison, a concentration of signals around TMS 5-a known "antiporter motif" is seen where residues are highlighted by the use of CRES and this provides internal validation for the method.
A second AT-rich motif is seen further downstream (segment 3).
No conserved motif is seen in the flanking exons, except for a slight enrichment of purines at the last position of the upstream exon.
Since these words representing the motifs may not be present exactly in the sequences (see SPELLER for details), a motif is seen as an "external" object and called model.
Additionally, in single cell organisms, when the SILK motif is seen in the N-terminus its architecture is 'SILK-RVxF'; but in multi cellular organisms the motif is shifted to C-terminus and the architecture is reversed to 'RVxF-SILK'.
A leucine zipper motif is seen to play a key role in preventing mistargeting of the enzyme; a multistep process is revealed including a central role for N-linked glycosylation.
We note that this is also in partial agreement with a left-handed model of EphA1 presented in recent studies by Li et al. We have not observed long-lasting dimerization through the AX3G motif, although this motif was seen in transient helix interactions (e.g., Figure 4B).
