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This is because most trials only look at changing one component of a complex treatment at a time.
Currently, most trials only mention stratification when it was used but do not explicitly state when it was not used.
In most trials, only one of these events is considered the primary outcome and the others are secondary outcomes.
However, the long-term clinical significance of these changes remains unclear, as most trials only followed participants for a median of 1 2 years.
Most trials only included children with a well described epilepsy syndrome such as BECTS [ 19, 22] or absence epilepsy (childhood absence epilepsy [CAE], juvenile absence epilepsy [JAE]) [ 20].
In most trials, only surrogate endpoints based on albuminuria were assessed, and, for several of the trials, hard endpoints for chronic kidney disease (doubling of serum creatinine concentration or end-stage renal disease) were not reported.
Similar(54)
6 Intervention trials have shown modest cardiovascular benefits of reducing intake of saturated fat while increasing intake of polyunsaturated fat, 7 but most trials lasted only up to two years and examined surrogate outcomes.
On average, protocols addressed less than 1/3 of recommended PRO items, with most trials offering only basic information, such as the PRO assessment schedule and questionnaires used [25].
However, our results highlighted that most trials involved only one centre and one or two surgeons, and the applicability of results from such trials is probably debatable.
For example, most trials were only of short-term duration (e.g. mean 6.25 weeks [ 4]) and it is therefore not possible to draw conclusions about the long-term efficacy.
Most trials balanced on only one or two prognostic factors (n=87; 78%), whereas 24 trials (22%) used between three and eight factors.
Related(20)
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