Sentence examples for most significant modules from inspiring English sources

One protein in particular, the heat shock 70 kDa protein A1 (HSPA1A), was found in all of the most significant modules for these two groups.

Interestingly, for two of the three autoimmune diseases tested (RA and T1D), the most significant modules were exclusively composed of HLA genes (Fig.  4).

As demonstrated in Figure  5, the four most significant modules identified in MS show almost no association with any other disease.

The default setting is to display the six top modules as separate entities, allowing the user to focus on the most significant modules of the network.

The enrichment results are reported in Additional file 2. Here, we highlight results for the two most significant modules: Magenta and Turquoise.

For the four most significant modules, however, the differences in cor(K C) were > 1, indicating that the standardized C(k) curve had flipped from negative (CTRL) to positive (HD).

Consistently with all previous genetic studies in MS, the most significant module (MS_I) included several HLA genes (Fig.  3A).

In T2D, the most significant module contained genes involved in intracellular signaling (EGFR and BCR), apoptosis (IGF1R, AVEN and APAF1) and insulin receptor signaling pathway (IGF1R and IGF2).

Interestingly, HLA-DRB5, present in the most significant module, is part of the DR15 haplotype and has been identified as a potential modifier of the disease (17, 18).

In addition the present study focuses on the most significant network modules identified, however some of the proteins identified in [24] were found among less significant modules identified in the present study (data not shown).

Table 1 lists the most significant network modules in each HLA risk group with information on bait proteins, the number of interaction partners within and outside the HLA region and p-values before and after correction with the reference.