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For each of the six HLA risk groups, we found more enrichment amongst the most significant clusters than we did when combining the samples across all HLA groups.
The most significant clusters of each LC6 on the 162×162 Kohonen map, are found on their particular density map up to 5 neighbours (defined above in Data Classification by KNN), where we choose the three largest maxima.
We have recently developed a novel algorithm which extends the original module network concept of Segal and co-workers [10] by using probabilistic optimization techniques which enable prioritization of the statistically most significant clusters of co-expressed genes and their candidate regulators [11], [12].
The next two most significant clusters also had complementary patterns.
The second (left temporal lobe), third (cerebellum), and fourth (parieto-occipital) most significant clusters had similar noncanonical, positive, responses.
The next two most significant clusters corresponded to mostly negative responses at locations remote from the presumed focus.
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The next most significant cluster of excuses?
The most significant cluster as determined by average silhouette score statistic is located inside the coding sequence of Complement component 5 gene (C5) that is already known as an asthma susceptibility gene reported in previous studies [29].
The most significant cluster is the four-gene cluster on chromosome 2 (p-value = 1.3·10-3).
In addition, only the two most significant clustering analyses were included in the table.
The largest and most significant cluster that exhibited this effect was in the left prefrontal cortex.
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