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As Backhaus and Faust indicated, it is a crude simplification to add the impact of a chemical where the most sensitive receptor is fish to one where the most sensitive receptor is an invertebrate (25).
As discussed above, the RVs for ecological effects are usually based on the most sensitive receptor which varies across different chemicals.
Further, the gene homologous to dgcalpha1 in rodents and humans is "guanylate cyclase 1, soluble, alpha 2" (GUCY1A2), which is one of the genes that encodes soluble guanylyl cyclase (sGC), the most sensitive receptor for nitric oxide [ 69].
Theoretically, the most sensitive receptor configuration consists of a single cluster of transduction sites connected to a single heminode, as found in invertebrate stretch receptors (Edwards and Ottoson, 1958).
Such diversity should enable the VNO to detect the threshold concentration of the ligand with the most sensitive receptor, as well as to accommodate high concentrations of the ligand that can fully activate several receptors.
Similar(55)
In seeking information about the environment, the nervous system presents the most-sensitive receptors to a stimulating object.
This involves the introduction of an objective odour limit, as follows: "Facilities that are identified as sources of potentially offensive odours shall ensure that the 10-min average concentration of odour resulting from all sources at the facility and determined in accordance with accepted procedures, shall be less than 1 odour unit 99.5% of the time at the most impacted sensitive receptor".
However, these mechanisms were consistently ranked the most sensitive irrespective of receptor activation.
A few studies, however, have detected a third photopic receptor most sensitive to medium wavelengths between 500 and 520 nm, overlapping in spectrally sensitivity with the feline scotopic receptor, that potentially could allow trichromatic vision.
The c-di-GMP receptor YcgR is one of the most sensitive c-di-GMP receptors described thus far.
The membrane receptors for prostanoids are termed P receptors, with a preceding letter indicating the natural prostanoid to which each receptor is most sensitive, i.e. DP, EP, FP, IP and TP for PGD2, PGE2, PGF2, PGI, and TXA2, respectively [ 13, 14].
Related(20)
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