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Those who believe in the naturalness of their economic and academic entitlement prove the most problematic, as they will come to see themselves as superior, even more deserving, than those who were dealt worse hands as children.
This type of contamination, occurring before sampling, is most problematic as it is impossible to control for [26].
Within the Caloosahatchee River, increases in salinity that led to P. pectinata occurring upriver of the study area may be most problematic as the river becomes quite narrow with few shallow habitats that this species appears to use as a refuge from predation [22].
Systematic errors (or bias) are by far the most problematic as they are generally not measured and they do not decrease as the sample size increases.
Among various groups of dyes, reactive dyes are the most problematic, as their complex aromatic structures are resistant to bio-degradation [ 6].
This study confirms that there are varied definitions of absenteeism that depend on the context in which the study is conducted, the availability of informative routine data and the factors investigators consider to be most problematic as causes.
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These peak effectiveness times coincided with the times of day patients reported as being most problematic at the beginning of the study and covered homework time.
Despite solid performances early in the campaign, the two-hour events have become Mr. Romney's most problematic forum as he tries, and fails, to compete with his rivals, and the audiences who seem to love them.
Since the global eradication of smallpox in 1977, monkeypox virus has been considered the most problematic orthopoxvirus as regards human health [1].
The last aspect the secrecy within families and lack of informed consent even in adolescents is in fact now considered the most problematic issue, as it immunized physicians' and parents' convictions from being falsified.
HPV-16 is the most problematic type as it causes at least half of all cervical cancers and the great majority (approximately 90%) of the HPV-associated cancers at the other anogenital sites and oral cavity.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com