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In contrast, GCP-WD is absolutely required for γ-tubulin recruitment and seems to function more proximal to the γTuRC in the recruitment pathway, most likely downstream of Cep215/pericentrin.
The most likely downstream target for Rnd3 on membranes is p190RhoGAP, which leads to downregulation of RhoA and hence loss of stress fibers and cell rounding.
Dorsally enriched MGE genes are most likely downstream effectors of the Gli transcription factor family, part of the SHH signaling pathway (Xu et al., 2005), and transcriptional targets of Nkx6.2.
In ischemic preconditioning, it has been shown that PKC is most likely downstream of the adenosine receptor, because the combination of PKC activation and adenosine receptor blockade was protective, whereas adenosine receptor activation in combination with PKC blockade was not [ 13].
Recently, Achard et al. has shown that activated ethylene signalling reduces bioactive Gibberellin (GA) levels and enhances the accumulation of DELLAs, and ethylene acts on DELLAs via the CTR1-dependent ethylene response pathway, most likely downstream of the transcriptional regulator EIN3.
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Thus, fzy-1 is most likely a downstream regulator of bub-1, but not fzr-1, in C. elegans.
We also show that, unlike stress-induced autophagy, an NADPH oxidase inhibitor does not inhibit the constitutive autophagy in these plants, indicating that AtTOR is most likely either downstream of or in a parallel pathway to NADPH oxidase.
Moreover, activation of Akt most likely acted downstream of ROS production.
Therefore, the combined evidence suggests that the blood-borne cardioprotective factor is most likely produced downstream of the neural pathway.
Detection of heterozygosity most likely occurs downstream of interhomolog strand invasion and the formation of base pair mismatches.
WRI1 most likely operates downstream of LEC1 and LEC2 and induces expression of genes encoding enzymes involved in glycolysis and fatty acid biosynthesis [ 103, 129].
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