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Macrophages are one of the most important effector cells of the innate immune system, and play pivotal roles in the response to graphene exposure.
During the SIMBOX (Science in Microgravity Box) mission on Shenzhou-8, we investigated microgravity-associated long-term alterations in macrophageal cells, the most important effector cells of the immune system.
To our knowledge, this is the first study demonstrating that an ECF sigma factor is the most important effector of lysozyme resistance in a bacterium.
Recruited at the membrane, PDK1 phosphorylates a key residue within the catalytic domain of one of its substrates, PKB [8], which is the most important effector of the PI3K pathway.
Phagocytosis of pathogenic microorganisms is one of the most important effector functions of neutrophil granulocytes.
Among them, granzyme B is the most important effector molecule for target-cell apoptosis [ 35].
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The primary results revealed that the IPTG concentration, Ca2+ ion concentration and induction time are the most important effectors on protease secretion by recombinant E. coli BL21.
The Ang II is the most important effectors of RAS and has an important role in controlling the glomerular filtration rate by influencing the contractility of glomerular arteries in the renal tubule, thus regulating glomerular capillary internal pressure (Mizuiri, Hemmi, Arita, Ohashi, Tanaka, et al., 2008).
Although caspase-9 functions as one of the most important effectors in the apoptosis, the lack of a minimal substrate consensus sequence for Akt [9] led us to exclude this from the candidates.
The relevance of the effector cells used in ADCC assays in vitro also remains to be defined: NK cells are most commonly employed in this context but are not necessarily the most important effector-cell population for all tumours in vivo.
One of the most important effectors studied that manipulates the actin cytoskeleton by EHEC-EPEC is translocated intimin receptor (Tir).
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