Sentence examples for most potent effector from inspiring English sources

It is well known that TNF is one of the most potent effector cytokines in the pathogenesis of IBD [41].

In the field of cancer immunotherapy research, the retargeting of T-cells to tumor cells by bispecific antibodies (BsAbs) is an appealing therapeutic concept because cytotoxic T-cells range among the most potent effector cells of the immune system [ 31, 32].

Furthermore, by a series of cell sorting experiments, we not only identify the phenotype of the most potent effector cell at day 8 but also, based upon this knowledge, uncover the precursor phenotype of Tck cells within normal resting peripheral blood lymphocyte population.

Among those effectors, CD8+ cytotoxic T lymphocytes (CTLs), which specifically recognize tumor-derived peptide epitopes presented on their surface in association with class I MHC molecule are the most potent effectors and such tumor epitope-specific CD8+ CTLs can be primed in vivo by immunization with epitope peptide-pulsed syngeneic dendritic cells (DCs) [ 1].

However, BAT-mediated thermogenesis is the most potent thermogenic effector mechanism and is exclusively mediated by uncoupling protein (UCP 1, downstream of β-adrenoceptor activation (7).

Evidence accumulated so far indicates that the immune system can influence the initiation and development of cancer and it is widely believed that T lymphocytes represent the most potent antitumor effector cells.

Our results demonstrate that the most potent Tck effectors are from a starting population of CD4+CD45RO+ memory T cells.

This is the book's single most potent effect.

GrB is one of the most potent and well-established effector molecules having the highest potential for targeted antitumor therapy due to the human origin of its enzymatic activity.

One of the most potent mechanisms of Treg-mediated effector T-cell suppression is the direct killing of effector cells by the granzyme/perforin pathway [ 23, 24].

However, this may indicate that the most activated cells have the potent effector function in the co-culture assay and that CD49d is a surrogate marker for this activity.