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The most frequent gain in PIOL (13/16; 81%) was located on 1q, which was also the most frequent gain (8/12; 67%) in IOCNSLs (Fig. 2a).
The most frequent gain regions of PIOLs and IOCNSLs were located on 1q.
As mentioned above, 5p15 was one of the most frequent gain sites in invasive LS−/TC+ UGCs (8/26; 30.7%), but was not detected in any of the 37 intramucosal and invasive LS+ UGCs.
As the 17q25.3 gain was the most frequent gain in our BRCA1-mutated population, and has not yet been described in the context of BRCA1 mutation, we have decided to characterize it further.
The most frequent gain of function mutations is seen in phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 9 (PIK3CA) which forms one of the catalytic subunits of the phosphatidylinositol 3-kinase (PI3K) holoenzyme [ 3, 4].
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The most frequent gained region was 1q followed by 13q.
In contrast, CN gains on 1q, which were the most frequent gains in PIOLs, were found infrequently (<10%) in FL, MALT lymphomas, and MCL.
Chromosome 20 showed a common pattern being one of the most frequent gains both in near-diploid and near-triploid NBTs.
The aCGH data set was studied further by identifying commonly aberrated regions [ 33], which showed most frequent gains in 8q and 1q.
The 10 most frequent gains and losses for each gene class are shown in Additional file 4 (complete list available on request).
Conversely, the three most frequent gains found in DLBCL (>30%; 1q, 12q, and 18q) were detected in >63% of PIOLs (Figs. 1, 2a).
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