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Thus, in familial BWS, where CDKN1C mutations are the most frequent abnormality [ 22], a scoring system designed to predict an abnormal 'BWS methylation assay' would not be appropriate as a normal IC1/2 methylation profile and a positive family history of maternally inherited BWS would indicate a requirement for CDKN1C mutation analysis [ 25].
The most frequent abnormality was monosomy X (45,X0).
The most frequent abnormality is maternal duplication 15q11-13, which account for ∼1 3% of autism [13].
The most frequent abnormality was lymphopenia (n=15, 63%).
The 6q deletion was the most frequent abnormality and was found in 37% of Korean patients.
The most frequent abnormality was loss of chromosome 18 observed in 70% of the cases.
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The most frequent abnormalities were located in the cortex (17%), the basal ganglia (15%) and the white matter (15%).
The most frequent abnormalities indicating loss of function at the control site of arthralgia and OA patients were MDT and WDT, and MDT and CDT, respectively.
The most frequent abnormalities were somatosensory gain to pinprick (35.0 %) and pressure (35.0 %) stimuli, somatosensory loss to pinprick (25.0 %), cold (22.5 %), and heat (15.0 %) nociceptive stimuli.
The most frequent abnormalities diagnosed on secretin-enhanced MRCP images were diffusely dilated side branches (25.6 %), diffuse main pancreatic duct dilation and delayed emptying of the main pancreatic duct (14.4 %) [21].
The development of increased gut permeability and mucosal inflammation are the most frequent abnormalities in NSAID users [ 41].
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